Friday, July 06, 2007

MGMT gene silencing and temozolamide in GBM

Hegi et al. NEJM 2005; 352:997-1003

Epigenetic gene silencing of the MGMT (06 methylguanine DNA methyltransferase) DNA repair gene by promoter methylation compromises DNA repair and is associated with longer survival in GBM patients receiving chemotherapy. This was also found to be true in radiotherapy; patietns with a methylated MGMT promoter had a survival benefit.

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