CNS complications of HPCT

Denier et al. Spectrum and prognosis of neurologic complications after hematopoeitc transplantation. Neurology 2006;67: 1990-1997.

Modern study. Ablation of bone marrow with allogeneic grafts are treated with prophylaxis against previously common events such as veno-occlusive disease and pulmonary complications. Now neurologic disease is a major cause of M/M. They occurred in about 16 % of patients receiving HPCT, usually opportunistic infections. Toxoplasmosis was the most common cause (33%) with others getting viral encephalitis, HSVE, and less commonly, metabolic encephalopathy, stroke, peripheral nervous system dysfunction.