from Continuum 2009
1. Absolute contraindication-- curare, d-penicillamine, botulinum toxin, interferon alpha
2. Contraindicated
a. Antibiotics-- aminoglycosides (gentamycin, kanamycin, neomycin, streptomycin, tobramycine); macrolides (erythromycin, azithromycin (Z-pack), telithromycin, Biaxin)
Fluoroquinolones ( ciprofloxacin, norfloxacin, levofloxacin);
b. quinine, quinidine, procainamide,
c. magnesium salts, iv magnesium replacement.
3. Caution- may exacerbate weakness in some myasthenics
a. Calcium channel blockers
b. Beta blockers
c. Lithium
d. Statins
e. Iodinated contrast agents
article on public domain
http://www.ispub.com/journal/the-internet-journal-of-neurology/volume-10-number-2/drugs-which-may-exacerbate-or-induce-myasthenia-gravis-a-clinician-s-guide.html
link to article by Pascuzzi discussing contraindicated drugs in more detail
http://myasthenia.org/LinkClick.aspx?fileticket=JuFvZPPq2vg%3d
1. Absolute contraindication-- curare, d-penicillamine, botulinum toxin, interferon alpha
2. Contraindicated
a. Antibiotics-- aminoglycosides (gentamycin, kanamycin, neomycin, streptomycin, tobramycine); macrolides (erythromycin, azithromycin (Z-pack), telithromycin, Biaxin)
Fluoroquinolones ( ciprofloxacin, norfloxacin, levofloxacin);
b. quinine, quinidine, procainamide,
c. magnesium salts, iv magnesium replacement.
3. Caution- may exacerbate weakness in some myasthenics
a. Calcium channel blockers
b. Beta blockers
c. Lithium
d. Statins
e. Iodinated contrast agents
article on public domain
http://www.ispub.com/journal/the-internet-journal-of-neurology/volume-10-number-2/drugs-which-may-exacerbate-or-induce-myasthenia-gravis-a-clinician-s-guide.html
link to article by Pascuzzi discussing contraindicated drugs in more detail
http://myasthenia.org/LinkClick.aspx?fileticket=JuFvZPPq2vg%3d
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1 comment:
Thanks for your list. I have seronegative myasthenic syndrome for 22 years. I HAVE found that tonic water (quinine), magnesium laxative in a Fleets, erythromycin, zithomax, cipro have made me weak. K-lyte when very weak has made me stronger for awhile. I am on atenolol and quinapril (any quinine in quinapril) for high blood pressure. Any ideas for best blood pressure med? Unfortunately I am also obese -240 pounds--from prednisone in the past, inability to exercise or to say "no" to food.
I have two sisters who also have what I have. We got sick in our twenties and early thirties.
I will keep list for myself and doctors.
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