Medications that reduce seizure threshold

from Neurologic Clinics 2008

Antidepressants esp. buproprion and maprotilene
antipsychotics especially phenothiazines and clozapine
Lithium
baclofen
AED withdrawal
super high phenytoin levels
theophylline
Analgesics esp. meperidine-demerol, fentanyl and tramadol
opiod withdrawal
benzodiazepine withdrawal
barbiturate withdrawal
antibiotics-- beta lactams (cefezolin), carbapenems (imipenem), quinolones, isoniazid (treat with B6), metronidazole
antiarythmics-- lidocaine, digoxin, mexelitine
radiographic contrast dyes
immunomodulators-- cyclosporine, tacrolimus, interferons
chemotherapeutic drugs-- alkylating agents such as chlorambucil and busulfan
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