Jammoul A, Shayya L, Mente K
et al. Neurology Clinical Practice 2016; 6:409-418.
Authors differentiate "classic" group with limbic encephalitis or neuromyotonia (9.6% of total) and note the others had a panoply of diagnoses that were nonclassic. The classic group was more likely to have high titers of ab, but there was overlap. 91 % of lcassic and 21 % of nonclassic had levels > 0.25 nM. 75 % of patietns in high level ab group had autoimmune disorders, and 75 % of patients with low level titers did not. 26 % of patients had a remote malignancy (active, remote, solid or hematologic) but not ab titer difference was noted among the groups .
Conclusions: 1. High VGKC ab levels are found in patients with classic and other autoimmune disorderes, Low level ab titers are seen in nonspecific and mostly nonautoimmune disorders
2. The presence of VGKC antibodies rather than the level may serve as a marker of malignancy
Notes this is bad on a chart review of 6,032 patients who underwent evaluation .
The nonclassic group includes PNS and CNS diorders including neuropathy, dementia, ALS, CJD. Some patietns had nonspecific symptoms such as stutering speech, nausea and vomting and orthostasis without diagnosis of neurologic disease.
Cancers were oftendiagnosed due towhole body CT/PET; 2 patietns had previously unknown cancer (Ovarian and lung). Cancer occurred more commonly in those over age 45. Many cases of ab finding were remote by over ten years from actual tumor.
Authors differentiate "classic" group with limbic encephalitis or neuromyotonia (9.6% of total) and note the others had a panoply of diagnoses that were nonclassic. The classic group was more likely to have high titers of ab, but there was overlap. 91 % of lcassic and 21 % of nonclassic had levels > 0.25 nM. 75 % of patietns in high level ab group had autoimmune disorders, and 75 % of patients with low level titers did not. 26 % of patients had a remote malignancy (active, remote, solid or hematologic) but not ab titer difference was noted among the groups .
Conclusions: 1. High VGKC ab levels are found in patients with classic and other autoimmune disorderes, Low level ab titers are seen in nonspecific and mostly nonautoimmune disorders
2. The presence of VGKC antibodies rather than the level may serve as a marker of malignancy
Notes this is bad on a chart review of 6,032 patients who underwent evaluation .
The nonclassic group includes PNS and CNS diorders including neuropathy, dementia, ALS, CJD. Some patietns had nonspecific symptoms such as stutering speech, nausea and vomting and orthostasis without diagnosis of neurologic disease.
Cancers were oftendiagnosed due towhole body CT/PET; 2 patietns had previously unknown cancer (Ovarian and lung). Cancer occurred more commonly in those over age 45. Many cases of ab finding were remote by over ten years from actual tumor.
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