Wednesday, November 13, 2019

Dermatomyositis with and without anti Mi2 autoantibodies

Pinal-Hernandez I, Mecoli CA, Casal-Dominguez M .  More prominent muscle involvement with dermatomyositis with anti Mi2 autoantibodies. Neurology; 2019; 93e1768-1777
(John Hopkins)

58 patients with antiMi2 positive DM
143 patient with anti Mi2 negative DM
162 patients with antisynthetase syndrome
170 patients with immune mediated necrotizing myopathy (IMNM).

Features of   patients with antiMi2 positive DM: more muscle weakness, less calcinosis , less interstitial lung disease, higher CK level but still stronger with lower CK's than pats with IMNM

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