Myoclonus Associated with the Use of Gabapentin
v Of 104 consecutive patients treated with
gabapentin, 13 (12.5%) developed myoclonus
v All patients (age 14 to 41 years) had refractory
partial epilepsy, 6 had a static encephalopathy
partial epilepsy, 6 had a static encephalopathy
v Myoclonus was multifocal in 10, contralateral to
the epilepticus focus in 3
the epilepticus focus in 3
v Myoclonus persisted for as long as gabapentin
was continued. Disappeared on drug withdrawal.
was continued. Disappeared on drug withdrawal.
v An EEG recording in 3 patients showed no
correlate
correlate
J. Asconapé et al., Epilepsia 2000:41:479-82
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