Thursday, December 28, 2006

Fludaribine for MGUS

Niermeijer JMF et al. Neurologic and hematologic response to fludaribine treatment in IgM MGUS polyneuropathy. Neurology 2006:67:2076-2079.

Uncontrolled trial of 16 patients with IgM with progressive IgM MGUS treated with fludaribine.
Patients: 6 were MAG positive, 14 had kappa light chain, 2 had lambda light chain, 3 had axonal neuropathy and 13 had demyelinating neuropathy. 9 used ambulation aids.

10/16 were first treated with cyclophosphamide/prednisone

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