Radiation retinopathy

Grimm et al. Retinopathy in survivors of primnary CNS lymphoma. Neurology 2006:67:2060-2062.

Study reports specifically five survivors of PCNSL who developed syndrome, 1.5 % of database. Patients received high dose MTX then WBRT then post-XRT chemo including procarbazine, vincristine, and carmustine. Mean latency to developing syndrome was 27 months. Note- syndrome is also reported in other diseases treated with WBRT.

Presentation was blurred vision (2/5), partial visual loss (3/5) and floaters (1/5). Fluroscein agio confirmed bilateral disease in 3. Treatments given include intraocular steroids and laser therapy. No patients had progressive ocular disease although one had radiation dementia and another had ongoing PCNSL.