Saturday, April 21, 2007

Applause sign is specific clinical test for PSP

Dubois B et al. "Applause sign" helps to discriminate PSP from FTRD and PD. Neurology 2005;64: 2132-2133. When asked to clap three and only three times as quickly as possible, after demonstration by examiner, an inability to stop clapping indicates PSP. Clapping from 4->10 times is abnormal. An applause sign was seen in 71 % of patients with PSP but none with FTD or PD.

a separate article described superior cerebellar atrophy in PSP

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