Saturday, April 21, 2007

Rash to yellow dye in levodopa-carbidopa

Chou KL , Stacy MA. Skin rash associated with simemet does not equal levodopa allergy. Neurology 2007; 68: 1078-9. Patients experiencing a rash on sinemet requiring stopping and rechallenging were actually allergic to a yellow dye (D&C Yellow 10 and FD&C Yellow 6) and were able to tolerate forms of levodopa not containing the dye. The safe forms included C/L 25/250 or 10/100 , CR forms of Sinemet, Stalevo and Parcopa, or Madopar (benserazide/levodopa).

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